Quick Test: What's Exclusion Criterion #17 in Your Pivotal Study?

Your PI can't remember either. But they're making enrollment decisions based on it right now—along with 86 other sites across 14 countries, each interpreting your protocol slightly differently. TrialPulse eliminates protocol interpretation variability with AI-driven real-time intelligence.

Your Medical Monitor can't be everywhere. TrialPulse can.

The Operational Vulnerability Costing

Adding 3-6 Months to Every Timeline

Sites don't remember your protocol. They reviewed it once during SIV—8 months ago—while juggling 11 other studies. Since then? Memory fades. Criteria blur. Decisions get made on incomplete recall instead of protocol precision.

The Scale of the Problem

Concurrent clinical trials. Hundreds of amendments. One fading institutional memory.

50+
Active protocols

At a single research institution—more than any one mind can hold.

247
Pages per protocol

On average—plus four to nine amendments over the life of the trial.

4 months
Since most sites read it

Yet enrollment decisions against that protocol happen every day.

Screen failures climbing

Wasting site budgets on ineligible patients

Data integrity eroding

87 sites, 87 slightly different interpretations

Protocol deviations discovered late

At monitoring visits, when it's too expensive to fix

Diversity goals missed

Sites over-exclude to 'play it safe'

Enrollment timelines slipping

Sites hesitate on borderline cases

Operational chaos

Hoping sites 'remember better' isn't a strategy—it's how enrollment timelines fail

You can't control enrollment speed when you can't control protocol interpretation.

The Operational Truth

Three forces are converging.

01

Sites are overloaded

The average research coordinator carries the operational memory for eleven concurrent trials.

02

Amendments are accelerating

Oncology protocols now average four to nine amendments per trial—and the cadence keeps rising.

03

Physicians are out of time

A PI has eight minutes between rooms. They cannot memorize 250 pages—and they shouldn't have to.

The Category Shift

Protocols have outgrown the systems that were built to store them.

Yesterday · CTMS · eReg · EDC

  • Built to store, route, and track documents
  • They hold the protocol—they don't operationalize it
  • Value lives at the data layer
  • Cognition stays with the human

Today · Protocol Intelligence

  • Reads the protocol so your people don't re-read it
  • Operationalizes the protocol at the decision
  • Value moves to the decision layer
  • Cognition is shared between human and system
The Solution

Protocol Intelligence That Turns Confusion Into Confidence

TrialPulse is the Protocol Intelligence Platform that transforms your 247-page static PDF into real-time, AI-driven guidance—delivered instantly to every site, at every decision point.

Think of it as a medical monitor in every coordinator's pocket—answering eligibility questions in seconds, preventing deviations before they happen, and keeping your study top-of-mind from SIV through last subject enrolled.

With TrialPulse, global studies move faster, cleaner, and with dramatically less risk. Your sites stop guessing. Your timelines accelerate. Your portfolio becomes predictable.

Clinical research team using TrialPulse
The Burnout Multiplier

Cognitive load is the new burnout.

Coordinators don't leave the profession because of patients. They leave because of paperwork. TrialPulse takes the heaviest cognitive work—reading and re-reading protocols—off their plate.

18 minutes
Before

per protocol question for a senior coordinator.

5 seconds
With TrialPulse

protocol cited answers.

Research coordinator reviewing a protocol on a tablet
Amendment Intelligence

Reading an amendment is not the same as operationalizing one.

01

Detect

AI parses the new amendment against the prior version and surfaces every operationally relevant change.

02

Acknowledge

The right people—by role, by site, by trial—are routed the change and required to acknowledge it.

03

Comprehend

Brief comprehension checks confirm the change was understood, not just clicked.

See It In Action

Experience Protocol Intelligence In Real-Time

Watch how TrialPulse AI answers complex eligibility questions instantly. Try asking about medications, lab values, or protocol-specific criteria.

  • Can I enroll a patient currently taking metformin?
  • What's the washout period for prior immunotherapy?
  • Does a history of mild asthma exclude the patient?
  • Is an eGFR of 58 mL/min acceptable for enrollment?
Click a question

The protocol-aligned answer will appear here.

Real-time guidance at every decision point. TrialPulse AI delivers protocol-aligned answers in seconds, preventing deviations before they happen.

This is just a glimpse. The actual TrialPulse platform is trained on your complete protocol and provides answers tailored to your study's specific requirements.

See TrialPulse With Your Protocol
Outcomes, Not Features

The operational impact.

5s
Eligibility decision
down from 18 min
94%
Faster amendment detection
critical updates, instantly
72h
Protocol live
from upload to use
8–12
Coordinator hrs / wk
freed per coordinator
↓40%
Eligibility deviations
at the point of decision

Without TrialPulse vs. With TrialPulse

Without TrialPulse

  • PI reads 247-page protocol once during SIV, then relies on fading memory
  • Coordinator guesses on edge cases or spends 18 minutes searching through PDFs
  • Sponsors discover protocol deviations at monitoring visits—months after enrollment
  • Protocol means something different at each site—operational chaos
  • Sites trained once at SIV—new coordinators learn from colleagues' fading memory

With TrialPulse

  • AI delivers crisp eligibility summaries at every decision point
  • Study Staff asks AI and gets protocol-aligned answer in 5 seconds
  • Sites prevent deviations before they happen with real-time guidance
  • Every site operates from the same interpretation—harmonized globally
  • SIV materials accessible 24/7—new staff onboard instantly with on-demand training
Why TrialPulse

Everyone else built a database. We built the intelligence layer.

Trial search, matching, and clinical-trial databases all store information and leave the cognition to an overloaded human. TrialPulse reads the protocol and operationalizes it at the point of decision — a different category, and the one that moves enrollment.

The Category Map
CapabilityTrial databasesMatching toolsTrialPulse
Search by biomarker & variantPartialPartial Real-time
Open cohort / slot visibility Live
Cited eligibility answersPartial With citation
Amendment detect → verify End-to-end
Comprehension proof In-workflow
Portfolio risk intelligence Predictive

Controlled document security built for clinical research. Trusted by leading pharmaceutical companies and CROs worldwide.

21 CFR Part 11 CompliantComplete Audit TrailsSOC 2 Type II (audit in progress)
Built for Pharmaceutical Excellence

TrialPulse Serves:

Top 10 Pharmaceutical Companies

Enterprise sponsors running global pivotal programs.

Leading Global CROs

Contract research organizations managing multi-site studies.

Academic Medical Centers and Hospitals

Research institutions and their investigator networks.

TrialPulse Oncology Intelligence — searching open trial cohorts by biomarker, variant, cancer type and line of therapy

Schedule a Demo

Tell us a little about your study and we'll tailor the demo to your protocol.